Sustained release HGH a future possibility

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    Recombinant human growth hormone (rhGH) therapy for short stature must be administered as a daily injection because of its poor bioavailability and short half-life. In the present study, a sustained-release formulation of rhGH (SR-rhGH), DA-3003, was prepared using double emulsion solvent evaporation with poly(D,L-lactide-co-glycolide) (PLGA), zinc oxide and hydroxypropyl-beta-cyclodextrin (HPCD) as the release modulator, stabilizer, and aggregation-prevention agent, respectively. After a single administration of DA-3003, the elevated concentration of rhGH in plasma was sustained for 14 days in rats and 28 days in monkeys. The plasma concentration of insulin-like growth factor-1 (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3), which are pharmacodynamic markers of rhGH administration, increased and remained elevated for approximately 28 days in monkeys. Monkeys administered DA-3003 did not develop antibodies to hGH, indicating safety of the SR-rhGH formulation comparable to that observed with daily rhGH injections (Growtropin II). There were no significant differences in efficacy between Growtropin II (daily dose of 5 microg/animal for 14 days) and DA-3003 (weekly dose of 35 microg/animal for 14 days with a dosing interval of a week) in hypophysectomized rats, as assessed by changes in body weight and the width of the tibial growth plate. These results show that a sustained-release rhGH formulation, DA-3003, has the potential to be used safely and efficaciously in a weekly dosing regimen.

  • If nothing else, maybe this would make black/gray market pharma grade regular HGH cheaper.

    “28 days in monkeys” is promising

  • They have this for kids already.

  • [quote=“GHKid2019” pid=‘61463’ dateline=‘1563498359’]
    They have this for kids already.

    Screen name checks out

  • [quote=“Juice” pid=‘61533’ dateline=‘1563552018’]
    [quote=“GHKid2019” pid=‘61463’ dateline=‘1563498359’]
    They have this for kids already.

    Screen name checks out


  • Probably wouldn’t be available for use for years

  • Kind of makes you wonder about what secret peptides the pros are using.

    My theory is that these peptides (likely myostatin inhibiting) are only available to special people because of these reasons

    1. They are unstable and only good for a short time
    2. They are very expensive to make so they want to use them on people who have sponsors to pay for manufacture and also because they’ve already made it to a certain level with genetics/work ethic/regular PED usage
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